論文発表

• Advantages of FBPA PET in evaluating early response of anti-PD-1 immunotherapy in B16F10 melanoma-bearing mice:Comparison to FDG PET. Tatsumi M, Soeda F, Naka S, Kurimoto K, Ooe K, Fukui H, Katayama D, Watabe T, Kato H, Tomiyama N. Front Oncol. 2022 Dec 22;12:1026608.
• Comparison of the Therapeutic Effects of [211At]NaAt and [131I]NaI in an NIS-Expressing Thyroid Cancer Mouse Model. Watabe T, Liu Y, Kaneda-Nakashima K, Sato T, Shirakami Y, Ooe K, Toyoshima A, Shimosegawa E, Wang Y, Haba H, Nakano T, Shinohara A, Hatazawa J. Int J Mol Sci. 2022 Aug 21;23(16):9434.
• Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model. Liu Y, Watabe T, Kaneda-Nakashima K, Shirakami Y, Naka S, Ooe K, Toyoshima A, Nagata K, Haberkorn U, Kratochwil C, Shinohara A, Hatazawa J, Giesel F. Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):871-880.
• Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition. Kihara T, Yuan J, Watabe T, Kitajima K, Kimura N, Ohkouchi M, Hashikura Y, Ohkubo S, Takahashi T, Hirota S. Exp Mol Pathol. 2021 Dec;123:104692.
• New regional drug delivery system by direct epicardial placement of slow-release prostacyclin agonist promise therapeutic angiogenesis in a porcine chronic myocardial infarction. Miyagawa S, Mizoguchi H, Fukushima S, Imanishi Y, Watabe T, Harada A, Sakai Y, Sawa Y. J Artif Organs. 2021 Dec;24(4):465-472.
• Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability. Suzuki H, Kaizuka Y, Tatsuta M, Tanaka H, Washiya N, Shirakami Y, Ooe K, Toyoshima A, Watabe T, Teramoto T, Sasaki I, Watanabe S, Ishioka NS, Hatazawa J, Uehara T, Arano Y. J Med Chem. 2021 Nov 11;64(21):15846-15857.
• Evaluation of 64Cu-Labeled New Anti-EGFR Antibody NCAB001 with Intraperitoneal Injection for Early PET Diagnosis of Pancreatic Cancer in Orthotopic Tumor-Xenografted Mice and Nonhuman Primates. Matsumoto H, Watabe T, Igarashi C, Tachibana T, Hihara F, Waki A, Zhang MR, Tashima H, Yamaya T, Ooe K, Shimosegawa E, Hatazawa J, Yoshida S, Naito K, Kurihara H, Ueno M, Ito K, Higashi T, Yoshii Y. Pharmaceuticals (Basel). 2021 Sep 23;14(10):950.
• Evaluation of Integrin αvβ3 Expression in Murine Xenograft Models: [68Ga]Ga-DOTA-C(RGDfK) PET Study with Immunohistochemical Confirmation. Mitsuyuki K, Watabe T, Naka S, Liu Y, Tatsumi M, Shimosegawa E, Kato H. Diagnostics (Basel). 2021 Jul 19;11(7):1295.
• Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation. Hirai N, Watabe T, Nagamori S, Wiriyasermkul P, Tanaka Y, Romanov V, Naka S, Kanai Y, Liu Y, Tani N, Sakai T, Tatsumi M, Shimosegawa E, Kanai Y, Hatazawa J. Asia Ocean J Nucl Med Biol. 2020 Spring;8(2):102-108.
• Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma: 64Cu- and 225Ac-Labeled FAPI-04 in Pancreatic Cancer Xenograft Mouse Models. Watabe T, Liu Y, Kaneda-Nakashima K, Shirakami Y, Lindner T, Ooe K, Toyoshima A, Nagata K, Shimosegawa E, Haberkorn U, Kratochwil C, Shinohara A, Giesel F, Hatazawa J. J Nucl Med. 2020 Apr;61(4):563-569.
• Impact of 18F-PSMA-1007 Uptake in Prostate Cancer Using Different Peptide Concentrations: Preclinical PET/CT Study on Mice. Soeda F, Watabe T, Naka S, Liu Y, Horitsugi G, Neels OC, Kopka K, Tatsumi M, Shimosegawa E, Giesel FL, Hatazawa J. J Nucl Med. 2019 Nov;60(11):1594-1599.
• Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2. Aoki M, Watabe T, Nagamori S, Naka S, Ikeda H, Kongpracha P, Horitsugi G, Kanai Y, Shimosegawa E, Kanai Y, Hatazawa J. Ann Nucl Med. 2019 Jun;33(6):394-403.
• Microvascular Dysfunction Related to Progressive Left Ventricular Remodeling due to Chronic Occlusion of the Left Anterior Descending Artery in an Adult Porcine Heart. Yajima S, Miyagawa S, Fukushima S, Isohashi K, Watabe T, Ikeda H, Horitsugi G, Harada A, Sakaniwa R, Hatazawa J, Sawa Y. Int Heart J. 2019 May 30;60(3):715-727.
• Myeloid-Derived Suppressor Cells Infiltrate the Brain and Suppress Neuroinflammation in a Mouse Model of Focal Traumatic Brain Injury. Hosomi S, Koyama Y, Watabe T, Ohnishi M, Ogura H, Yamashita T, Shimazu T. Neuroscience. 2019 May 15;406:457-466.
• Preserved Cerebral Oxygen Metabolism in Astrocytic Dysfunction: A Combination Study of 15O-Gas PET with 14C-Acetate Autoradiography. Macaisa CM, Watabe T, Liu Y, Romanov V, Kanai Y, Horitsugi G, Kato H, Shimosegawa E, Hatazawa J. Brain Sci. 2019 May 3;9(5):101.
• Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice. Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T. Neuroimage Clin. 2018;20:946-954. doi: 10.1016/j.nicl.2018.09.031. Epub 2018 Oct 1.
• Transplantation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Is Superior to Somatic Stem Cell Therapy for Restoring Cardiac Function and Oxygen Consumption in a Porcine Model of Myocardial Infarction. Ishida M, Miyagawa S, Saito A, Fukushima S, Harada A, Ito E, Ohashi F, Watabe T, Hatazawa J, Matsuura K, Sawa Y. Transplantation. 2019 Feb;103(2):291-298. doi: 10.1097/TP.0000000000002384.
• Cell Spray Transplantation of Adipose-derived Mesenchymal Stem Cell Recovers Ischemic Cardiomyopathy in a Porcine Model. Mori D, Miyagawa S, Yajima S, Saito S, Fukushima S, Ueno T, Toda K, Kawai K, Kurata H, Nishida H, Isohashi K, Hatazawa J, Sawa Y. Transplantation. 2018 Dec;102(12):2012-2024. doi: 10.1097/TP.0000000000002385.
• Detection of neuroinflammation before selective neuronal loss appearance after mild focal ischemia using [18F]DPA-714 imaging. Miyajima N, Ito M, Rokugawa T, Iimori H, Momosaki S, Omachi S, Shimosegawa E, Hatazawa J, Abe K. EJNMMI Res. 2018 Jun 8;8(1):43. doi: 10.1186/s13550-018-0400-x.
• Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET. Rokugawa T, Konishi H, Ito M, Iimori H, Nagai R, Shimosegawa E, Hatazawa J, Abe K. EJNMMI Res. 2018 May 31;8(1):40. doi: 10.1186/s13550-018-0394-4.
• A prostacyclin agonist and an omental flap increased myocardial blood flow in a porcine chronic ischemia model. Yajima S, Miyagawa S, Fukushima S, Sakai Y, Isohashi K, Watabe T, Ikeda H, Horitsugi G, Harada A, Sakaniwa R, Hatazawa J, Sawa Y. J Thorac Cardiovasc Surg. 2018 Jul;156(1):229-241.e14. doi: 10.1016/j.jtcvs.2018.02.086. Epub 2018 Mar 11.
• Novel regenerative therapy combined with transphrenic peritoneoscopy-assisted omentopexy. Kainuma S, Nakajima K, Miyagawa S, Fukushima S, Saito A, Harada A, Hirota M, Miyazaki Y, Sawabata N, Watabe T, Watabe H, Toda K, Hatazawa J, Okumura M, Sawa Y. Interact Cardiovasc Thorac Surg. 2018 Jun 1;26(6):993-1001. doi: 10.1093/icvts/ivx430.
• Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms. Horitsugi G, Watabe T, Kanai Y, Ikeda H, Kato H, Naka S, Ishibashi M, Matsunaga K, Isohashi K, Shimosegawa E, Hatazawa J. EJNMMI Res. 2017 Oct 27;7(1):91. doi: 10.1186/s13550-017-0335-7.
• First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera. Kishimoto A, Kataoka J, Taya T, Tagawa L, Mochizuki S, Ohsuka S, Nagao Y, Kurita K, Yamaguchi M, Kawachi N, Matsunaga K, Ikeda H, Shimosegawa E, Hatazawa J. Sci Rep. 2017 May 18;7(1):2110. doi: 10.1038/s41598-017-02377-w.
• Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET. Watabe T, Hanaoka K, Naka S, Kanai Y, Ikeda H, Aoki M, et al. Ann Nucl Med. 2017.
• Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET. Watabe T, Kanai Y, Ikeda H, Horitsugi G, Matsunaga K, Kato H, et al. EJNMMI Res. 2017;7(1):16.
• 18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET. Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, et al. Eur J Nucl Med Mol Imaging. 2017;44(2):321-31.
• Development of PET Imaging to Visualize Activated Macrophages Accumulated in the Transplanted iPSc-Derived Cardiac Myocytes of Allogeneic Origin for Detecting the Immune Rejection of Allogeneic Cell Transplants in Mice. Kashiyama N, Miyagawa S, Fukushima S, Kawamura T, Kawamura A, Yoshida S, Harada A, Watabe T, Kanai Y, Toda K, Hatazawa J, Sawa Y. PLoS One. 2016 Dec 8;11(12)
• Development of a PET/OMRI combined system for simultaneous imaging of positron and free radical probes for small animals. Yamamoto S, Watabe T, Ikeda H, Kanai Y, Ichikawa K, Nakao M, et al. Med Phys. 2016;43(10):5676.
• Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia. Momosaki S, Ito M, Yamato H, Iimori H, Sumiyoshi H, Morimoto K, Imamoto N, Watabe T, Shimosegawa E, Hatazawa J, Abe K. J Cereb Blood Flow Metab. 2016 Feb 24.
• Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice. Kawamura A, Miyagawa S, Fukushima S, Kawamura T, Kashiyama N, Ito E, Watabe T, Masuda S, Toda K, Hatazawa J, Morii E, Sawa Y. Sci Rep. 2016 Jan 14;6:19464.
• Development of a prototype Open-close positron emission tomography system. Yamamoto S, Okumura S, Watabe T, Ikeda H, Kanai Y, Toshito T, Komori M, Ogata Y, Kato K, Hatazawa J. Rev Sci Instrum. 2015 Aug;86(8):084301.
• Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice. Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S. Metabolism. 2015 Sep;64(9):1165-74.
• Cell-sheet Therapy with Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. Kainuma S, Miyagawa S, Fukushima S, Pearson J, Chen YC, Saito A, Harada A, Shiozaki M, Iseoka H, Watabe T, Watabe H, Horitsugi G, Ishibashi M, Ikeda H, Tsuchimochi H, Sonobe T, Fujii Y, Naito H, Umetani K, Shimizu T, Okano T, Kobayashi E, Daimon T, Ueno T, Kuratani T, Toda K, Takakura N, Hatazawa J, Shirai M, Sawa Y. Mol Ther. 2015 Feb;23(2):374-86.
• FBPA PET in Boron Neutron Capture Therapy for Cancer: Prediction of 10Boron Concentration in the Tumor and Normal Tissue in a Rat Xenograft Model. Hanaoka K, Watabe T, Naka S, Kanai Y, Ikeda H, Horitsugi G, Kato H, Isohashi K, Shimosegawa E, Hatazawa J. EJNMMI Res 2014; 4:70.
• Distribution of Intravenously Administered Acetylcholinesterase Inhibitor and Acetylcholinesterase Activity in the Adrenal Gland: 11C-Donepezil PET Study in the Normal Rat. Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J. PLoS One. 2014;9(9):e107427.
• Development of a PET/Cerenkov-light hybrid imaging system. Yamamoto S, Hamamura F, Watabe T, Ikeda H, Kanai Y, Watabe H, Kato K, Ogata Y, Hatazawa J. Med Phys. Sep 2014;41(9):092504.
• Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations. Yamamoto S, Watabe T, Ikeda H, Kanai Y, Watabe H, Ogata Y, Kato K, Hatazawa J. Ann Nucl Med. 2014 Aug 8.
• Impact of cardiac support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model. Kubota Y, Miyagawa S, Fukushima S, Saito A, Watabe H, Daimon T, Sakai Y, Akita T, Sawa Y. J Thorac Cardiovasc Surg. 2014 Mar;147(3):1081-7.
• Quantitative evaluation of cerebral blood flow and oxygen metabolism in normal anesthetized rats: 15O-labeled gas inhalation PET with MRI Fusion. Watabe T, Shimosegawa E, Watabe H, Kanai Y, Hanaoka K, Ueguchi T, Isohashi K, Kato H, Tatsumi M, Hatazawa J. J Nucl Med. 2013 Feb;54(2):283-90.